~] vmkfstools -C vmfs6 -S USB_Datastore /dev/disks/mpx.vmhba34:C0:T0:L0:1 create fs deviceName:'/dev/disks/mpx.vmhba34:C0:T0:L0:1', fsShortName:'vmfs6', fsName:'USB_Datastore' deviceFullPath:/dev/disks/mpx.vmhba34:C0:T0:L0:1 deviceFile:mpx.vmhba34:C0:T0:L0:1 ATS on device /dev/disks/mpx.vmhba34:C0:T0:L0:1: not supported . Checking if remote hosts are using this device as a valid file system. This may take a few seconds... Creating vmfs6 file system on "mpx.vmhba34:C0:T0:L0:1" with blockSize 1048576, unmapGranularity 1048576, unmapPriority default and volume label "USB_Datastore". Successfully created new volume: 662db00c-ca962019-d624-20040fef52e0
To restore USB device access for passthrough to virtual machines without restarting:
Detach a USB device from ESXi hosts.
~] esxcli storage filesystem list Mount Point Volume Name UUID Mounted Type Size Free ------------------------------------------------- ------------------------------------------ ----------------------------------- ------- ------ ------------- ------------ /vmfs/volumes/662db00c-ca962019-d624-20040fef52e0 USB_Datastore 662db00c-ca962019-d624-20040fef52e0 true VMFS-6 255818989568 150051225600